Similarly, heterogeneous periodontal case definitions were applied in the included studies, different from the one introduced by the 2017 classification of periodontal and peri-implant diseases and conditions , and, consequently, staging and grading of periodontitis were not performed. In particular, the Community Periodontal Index, employedby Kadhim et al. and by Fernández et al. , is considered to be able to detect the prevalence but not the severity of periodontal disease . However, lower CAL values were reported in statin vs. non-statin users by Sayar et al. , who attributed such results to the anti-inflammatory effect exerted by statins, and by Cicek Ari et al., , although not reaching the statistical significance; conversely, opposite results were found by Poston et al. .
The regulatory and reimbursement landscape is evolving to become more favorable to incorporating digital health solutions. ST. LOUIS, MO—Deck Commerce, a company that helps retailers manage and optimize the entire order lifecycle, closed $7.8 million in Series A funding led by Plymouth Growth, a growth equity firm based in Ann Arbor, Michigan. This new partnership will allow Deck Commerce to enhance its product offering to feature more direct-to-consumer capabilities for leading brands. DURHAM, NC—SWIR Vision Systems, which develops image sensor solutions for industrial automation and autonomous vehicles, hasclosed a $5 million Series A financing round. The company’s technology enables the highest resolution and smallest form factor wavelength infrared sensors for key industrial, defense and emerging large market applications. TripleBlind is taking a new approach to enterprise-level data sharing that preserves privacy, and the startup just scored $24 million to keep up with strong demand for its technology.
Examples of evidence-backed approaches that could have digital health approaches include monitoring seizure frequency in epilepsy49, assessment of mood disorders in Parkinson disease50, and patient-reported outcomes in heart failure49–52. All of these examples also represent the collection of health data that may directly lead to changes in care, which affect clinical outcomes. Digital health solutions need not exceed the comparable in-person or traditional care options, but rather produce at least comparable outcomes while improving convenience, access, patient satisfaction, or cost. For example, a televisit is almost always superior to the scheduled in-person visit that never occurs due to transportation, child-care, or other access issues. Gingival crevicular IL-1 wassignificantly lower in statin compared to non-statin users , similarly to MPO and IL-6 levels, opposite to IL-10 ones . Tooth loss may benefit from systemically delivered statins, which may exert a protective effect in periodontal subjects .
This embrace will enable such institutions to pioneer cutting-edge digital health products, services, and approaches to advance care and mission. It requires a forward-leaning, risk-taking organization that can rapidly deploy and assess a solution’s impact while improving the solution with agility or “failing fast.” The measurement and assessment of deployed digital health technologies should be enabled by the organization’s research and quality improvement arms. Second, although academic centers should not implement technology for technology’s sake, they should become deeply familiar with the emerging technology and innovation landscape. Only through intimate knowledge, exploration, and use of cutting-edge solutions can their potential be embraced and realized.
TripleBlind plans to use the funds to support its technology’s use by digital health and biopharma companies, though it also sees some potential use cases in banking and financial services. Instead of manually de-identifying data, such as removing information on ages and genders, TripleBlind encrypts it and only allows the data to be used one time by the appropriate entity. For example, a healthcare company could allow a pharmaceutical company to run an analytics operation one time, and only using the information necessary for that task, CEO Riddhiman Das said. The health system and General Catalyst recently co-led a $24 million investment in TripleBlind, a startup whose analytics platform allows companies to collaborate without having to share raw data.
Fifth and finally, and related to embracing both impactful and cutting-edge digital health solutions, academic clinical institutions should capitalize on this deluge of data through research and reporting. They should study and report on the efficacy of promising new digital health technologies and approaches, championing the efficacious ones while transparently reporting unsuccessful tools. As noted previously, to be “early adopters” of cutting-edge technologies, the research arms of academic healthcare organizations are well-suited to establish and monitor the impact of digital health technologies.
The risk of bias was previously recorded for all of the items, as extensively shown in the risk of bias table. Hyperlipidemia is characterized by an increase in triglycerides , total cholesterol and low-density lipoprotein serum levels, coupled with a decrease in blood concentrations of high-density lipoprotein cholesterol . Hyperlipidemia is a well-recognized risk factor for cardiovascular disease , which, in turn, acts as a contributory factor in periodontitis development . Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world.
To do this, researchers must be given easy access to these new data sources. They should be armed with knowledge and resources to garner funding outside traditional sources such as the National Institutes of Health. Also, researchers will benefit from efficient organizational pathways to work with industry, where the bulk of digital health innovation resides. Academic institutions should also utilize digital health tools to foster implementation scientific research, which aims to identify the factors that affect real-world uptake of clinical interventions seemingly efficacious and effective in clinical trials71,72. A proactive strategic approach runs counter to the opportunistic and reactionary postures to digital health experienced by many academic medical centers before and since the ongoing Public Health Emergency.
This massive asymmetry of information and patient access greatly differentiates the two current states of academic medical centers and industry. Yet, academia is best poised not only to define the most david boey useful data to collect but also how to study it. We believe the most productive path will be through intelligent partnerships between academic and industry that align with each of their missions.