Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials

CR, CB, LB, JE, ES, KD, HH, LH, KW, CH, and AR accessed and verified the data. All authors critically revised the manuscript for important intellectual content. All collaborators had an opportunity to provide input into the study protocols, contribute to the interpretation of the results, and to critically revise the manuscript for important intellectual content.

Pravastatin belongs to a class of drugs called HMG-CoA reductase inhibitors. A class of drugs is a group of medications that work in a similar way. The information contained in the Truven Health Micromedex products as delivered by GoodRx is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment.

If you’re taking clarithromycin, talk with your doctor before using pravastatin. According to the drug’s manufacturer, you shouldn’t take a pravastatin dose above 40 mg while taking clarithromycin. Your doctor may decide to prescribe this dose, or they sexwithsluts. com may try a different medication for your condition. If you’re taking cyclosporine, talk with your doctor before taking pravastatin. According to the drug’s manufacturer, you shouldn’t take a pravastatin dose above 20 mg while taking cyclosporine.

According to the drug label, the cognitive issues were generally not serious and went away after patients stopped taking the drug. Though the reactions occurred less often, people who took the drug during clinical trials also reported nose bleeds, blurred vision and ringing in the ears. Still others reported fever, liver problems, abnormal blood and urine test results, and malaise, which is a general feeling of discomfort or uneasiness. The most common side effects of statins are abdominal pain, constipation, flatulence, nausea, headache, fatigue, diarrhea, and muscle complaints. Except for musculoskeletal symptoms, most side effects are infrequent. Contraindications, conditions that warrant withholding treatment with pravastatin, include pregnancy and breastfeeding.

Injection lessened the reduction in saliva secretion and restored the activity of salivary amylase . Statins have been investigated as a novel, alternative agent for pulp capping. Because statins exert anti-inflammatory properties as one of their many pleiotropic effects, they are of interest to practicing dentists and specialists alike. Pulp and periapical symptoms can be modulated with the use of statins, and they can also potentially decrease the development of apical periodontitis.

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